Association Between CytochromeP4501A2 and CytochromeP4502E1 Gene Polymorphisms and Metabolism of Theophylline

Zhujiang Hospital

Status: Completed

Conditions: Chronic Obstructive Pulmonary Disease

Treatments: Drug: theophylline

Study type: Interventional

Funder types: Other

Identifiers

NCT02001935

81302846

Details and patient eligibility

About

The aim of this study is to determine whether common CYP1A2 and CYP2E1 gene polymorphisms effect metabolism of theophylline in chronic obstructive pulmonary disease patients.

Enrollment: 102 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Aged 18-75 years,COPD patients, male or female;
• regularly visiting our hospital;
• taking a sustained-release preparation of theophylline continuously for at least 2 weeks

Exclusion criteria

• patients with renal or hepatic dysfunction;
• patients with congestive heart failure;
• patients with hypothyroidism or hyperthyroidism;
• patients currently taking drugs likely to affect theophylline metabolism or who had taken such drugs in the preceding week;
• patients with extreme obesity
• patients with very severe Chronic Obstructive Pulmonary Disease(COPD)

Trial design

102 participants in 1 patient group

theophylline

Other group

Treatment:

Drug: theophylline