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Association Between Different Parameters of Nutritional Assessment and Clinical Outcomes in Cancer Patients

F

Federal University of Minas Gerais

Status

Unknown

Conditions

Postoperative Complications
Cancer
Sarcopenia

Study type

Observational

Funder types

Other

Identifiers

NCT02901132
FUMinas Gerais

Details and patient eligibility

About

Malnutrition in oncologic patients has a negative impact on post- surgical recovery, survival and quality of life. The etiology of malnutrition in cancer patients is multifactorial, therefore, the nutritional assessment should be carried out by different parameters. The objective of this study is to investigate the association and prognostic value of five distinct methods of nutritional assessment (molecular, body composition, functional, anthropometric and subjective) in relation to postoperative complications and short-term survival in patients with cancer. Regarding the molecular parameter, mtor signaling pathwayon will be assessed in rectus muscle samples, harvested in the moment of the operation. Body composition was assessed by computed tomography (CT) and bioelectrical impedance test was conducted to evaluate the phase angle. Handgrip strength was used to determine functionality. The percentage of weight loss in relation to usual weight was the anthropometric parameter used. Subjective Global Assessment (SGA) was used to provide the nutritional diagnosis. Postoperative complications were classified according to the Dindo and Clavien classification. Overall time survival was the period between the first assessment of the patients until death or end of follow-up. Chi-square test, t test, Kaplan-Meier method and the Log Rank test and regression analysis will be used (p <0.05).

Enrollment

120 patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • Diagnostic cancer confirmed
  • Over 18 years old
  • Accepted the terms of survey

Exclusion criteria

  • Tumor synchronic
  • Inflamattory disease
  • Under 18 years old
  • No accepted the terms of survey

Trial design

120 participants in 2 patient groups

Cancer group 1
Description:
Colorectal cancer patients, under 18 years old, no inflammatory disease, weight loss greater 10% habitual body weight, sarcopenic.
Control group
Description:
No cancer patients, under 18 years old, no inflammatory disease, no weight loss, no sarcopenic.

Trial contacts and locations

2

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Data sourced from clinicaltrials.gov

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