Association Between Early FiO₂ Exposure and Changes in the Uric Acid/Albumin Ratio in Septic ICU Patients

Istinye University

Status: Not yet enrolling

Conditions: Hyperoxia / High FiO₂ Exposure; Uric Acid/Albumin Ratio (UAR)

Treatments: Other: Oxygen Exposure (Fraction of Inspired Oxygen, FiO₂) - Standard of Care (Observational, No Experimental Intervention)

Study type: Observational

Funder types: Other

Identifiers

NCT07332637

329-2025

Details and patient eligibility

About

This prospective, non-interventional study aims to investigate the relationship between early oxygen exposure and oxidative stress in adult intensive care unit (ICU) patients diagnosed with sepsis or septic shock. Fraction of inspired oxygen (FiO₂) levels administered during the first 24 hours of ICU admission will be evaluated in relation to changes in the uric acid/albumin ratio (UAR), a biochemical marker reflecting oxidative burden and inflammation. Serum uric acid and albumin levels will be measured at ICU admission and at 24 hours, and the percentage change in UAR (ΔUAR%) will be calculated. Associations between FiO₂ exposure parameters and ΔUAR% will be analyzed, along with secondary outcomes including 28-day mortality and oxygenation indices. The findings may help clarify whether excessive oxygen therapy contributes to oxidative stress and whether UAR can serve as an accessible biomarker of oxygen-related oxidative injury in septic ICU patients.

Enrollment: 110 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult patients aged 18 years or older
• Admission to the intensive care unit with a diagnosis of sepsis according to Sepsis-3 criteria
• Receipt of oxygen therapy with FiO₂ ≥ 0.3 during ICU stay
• Availability of serum uric acid, albumin, and lactate measurements and calculated SOFA scores at ICU admission
• Availability of serum uric acid and albumin levels both at ICU admission (baseline) and at 24 hours
• Provision of informed consent by the patient or a legally authorized representative

Exclusion criteria

• Age younger than 18 years
• Pregnant or breastfeeding women
• Chronic kidney disease or receipt of renal replacement therapy
• Advanced liver failure (Child-Pugh class C)
• Receipt of albumin infusion within the previous 24 hours
• Use of medications that affect uric acid metabolism (e.g., allopurinol, febuxostat, rasburicase)
• History of active gout attack or malignancy-related hyperuricemia
• Missing serum uric acid or albumin measurements at baseline or 24 hours
• Inability to obtain informed consent from the patient or a legally authorized representative