Association Between Erythroferron and Perioperative Hemoglobin Levels in Patient Undergoing Heart Valve Surgery

Yonsei University

Status

Completed

Conditions

Postoperative Anemia

Study type

Observational

Funder types

Other

Identifiers

NCT05384054

4-2022-0260

Details and patient eligibility

About

In patients undergoing cardiac surgery, perioperative anemia is an important factor in surgical recovery. In addition to the low preoperative hemoglobin level, the delayed recovery of the postoperative hemoglobin level is an important problem affecting the incidence of postoperative anemia. Erythroferron is the early response to of the red blood cell production in stressful situations such as anemia, bleeding, and hypoxia. Therefore, it is thought that acute blood loss and systemic inflammatory reaction that inevitably occurs after cardiac surgery will synthesize erythroferron, which helps to restore hemoglobin level at postoperative period by promoting hematopoiesis by simultaneously inhibiting hepcidin and activating hematopoiesis.

In this study, the investigators will investigate the association between Erythroferron and perioperative hemoglobin levels in patient undergoing heart valve surgery.

Enrollment

150 patients

Sex

All

Ages

20+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Patients older than 20 years
undergoing elective valvular heart surgery

Exclusion criteria

Emergency operation
Co-operation with other surgeries
Patients with cardiogenic shock or ventricular-assist device (eg. ECMO, IABP)
Patients requiring mechanical ventilator care in preoperative period
Patient with severe chronic kidney disease (GFR(CKD-EPI) <30ml/min/1.73m2)
Patients with preoperative infection status (Eg. Sepsis)
Patients with acute bleeding status
Hemoglobin concentration below 10g/dL
Disease directly affecting hematopoiesis (eg. Leukemia, myeloma, aplastic anemia)
Uncompensated liver cirrhosis, acute hepatitis, alcoholics
Patients who participated in other clinical studies that could affect prognosis
Patients who cannot understand the informed consent (eg. Foreigner)