Association Between Fibrinogen-to-albumin Ratio and Delirium After Deep Brain Stimulation Surgery in Parkinson's Disease

Naval Military Medical University

Status: Completed

Conditions: Parkinson Disease; Deep Brain Stimulation; Postoperative Delirium

Study type: Observational

Funder types: Other

Identifiers

NCT05833308

POD-FAR

Details and patient eligibility

About

Postoperative delirium (POD) remains one of the most common neuropsychiatric complications after deep brain stimulation (DBS) surgery. The fibrinogen-to-albumin ratio (FAR) has been shown to significantly correlate with prognosis of many diseases associated with inflammation, but the relationship between FAR and POD is unclear. The investigators aimed to investigate the association between POD and FAR in Parkinson's disease (PD) patients receiving DBS surgery. For this aim, the present study was conducted to provide a new method for the early recognition and perioperative management of delirium after DBS surgery in PD patients.

Enrollment: 226 patients

Sex: All

Ages: 55+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Over 55 years old
• American Society of Anesthesiologists (ASA) physical status I-III
• Bilateral subthalamic nucleus deep brain stimulation surgery

Exclusion criteria

• Preoperative delirium
• Missing preoperative laboratory parameters on fibrinogen or albumin
• Persistent infectious diseases
• Coagulopathy and autoimmune-illness or malignancies

Trial design

226 participants in 2 patient groups

POD group

Description:

Patients who were determined to have incident postoperative delirium by a positive confusion assessment method (CAM) questionnaire after operation were defined as the POD group.

Non-POD group

Description:

Patients who did not suffer from delirium after surgery consisted of the Non-POD group.