Association Between Gastroesophageal Reflux Disease (GERD) Severity and Dental Caries

Tanta University

Status: Completed

Conditions: Dental Caries; Gastroesophageal Reflux Disease; Severity

Treatments: Device: Endoscopy

Study type: Observational

Funder types: Other

Identifiers

NCT07108751

36264PR1280/7/25

Details and patient eligibility

About

This study aimed to assess the relationship between gastroesophageal reflux disease (GERD) severity (based on upper gastrointestinal endoscopy) and dental caries severity.

Full description

Gastroesophageal reflux disease (GERD) is a chronic condition characterized by reflux of stomach acid into the esophagus, with a prevalence reaching 20-30% in many populations. Beyond its gastrointestinal manifestations, GERD may have extraesophageal effects, including oral health disturbances such as dental erosion and caries. Exposure of the oral cavity to gastric acid, especially in patients with severe or nocturnal reflux, may contribute to enamel demineralization, increased tooth decay, and lower salivary pH.

Enrollment: 200 patients

Sex: All

Ages: 18 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age 18-65 years.
• Both sexes.
• Diagnosed with Gastroesophageal Reflux Disease (GERD) by endoscopy.
• Consent to participate.

Exclusion criteria

• Xerostomia-related disorders.
• Recent antibiotics (last 4 weeks).
• Head/neck radiation history.
• Cognitive impairment affecting consent.
• Pregnant or lactating women.
• HbA1c above 6.4%.

Trial design

200 participants in 2 patient groups

Study group

Description:

Gastroesophageal reflux disease (GERD) patients.

Treatment:

Device: Endoscopy

Control group

Description:

Matched control group.

Treatment:

Device: Endoscopy