Association Between Irisin, Inflammatory Markers and Metabolic Status in Obese Children With Type 2 Diabetes Mellitus

Instituto Tecnologico y de Estudios Superiores de Monterey

Status: Completed

Conditions: Pediatric Obesity; Diabetes Mellitus, Type 2

Study type: Observational

Funder types: Other

Identifiers

NCT03767608

AIEMPPDM2SM

Details and patient eligibility

About

The objective of this study was to investigate the association of irisin with inflammatory markers as well with metabolic and anthropometric parameters in children and adolescents with type 2 diabetes mellitus compared with healthy controls.

Full description

Mexican children and adolescents previously diagnosed with type 2 diabetes mellitus according to the American Diabetes Association (ADA) criteria were recruited and compared to healthy controls.

The participants will undergo:

• vital signs measurement (systolic and diastolic blood pressure, heart rate, respiratory rate)
• anthropometric variables measurement (BMI, weight, waist circumference, hip circumference, body fat %)
• laboratory studies: glucose, triglycerides, HDL-c, C reactive protein, irisin

After statistical analyses the investigators will compare the relationship of irisin and the inflammatory profile and the anthropometric parameters of diabetic patients versus lean controls.

Enrollment: 40 patients

Sex: All

Ages: 6 to 17 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Have been previously diagnosed with T2DM according to the American Diabetes Association (ADA) criteria .

Healthy controls were required to have:

• Normal weight according to the Centers for Disease Control and Prevention (CDC) criteria.
• No metabolic abnormalities on blood samples
• No previously diagnosed cardiometabolic diseases
• Not been using antihypertensive, lipid or glucose lowering medications

Exclusion criteria

• Disapproval by the children's physician due to any at-risk medical condition known by the parents
• Use of drugs for high blood pressure, hyperglycemia, or dyslipidemia

Trial design

40 participants in 2 patient groups

Patients with type 2 diabetes mellitus

Description:

Patients diagnosed with T2DM according to the ADA

Lean healthy controls

Description:

Lean healthy controls