Association Between Light Spectrum and Survival After Cataract Surgery

University of Pittsburgh

Status: Completed

Conditions: Age Related Macular Degeneration; Cataract; Glaucoma; Age-related Cataract; Circadian Rhythm Disorders

Treatments: Device: Blue-light filtering intraocular lens; Device: Conventional intraocular lens

Study type: Observational

Funder types: Other

Identifiers

NCT04187157

PRO18060034

Details and patient eligibility

About

This study was a retrospective observational cohort analysis of subjects aged 65 years and older, who underwent bilateral cataract surgery within a single (15 hospital) healthcare system, to determine the association between type (conventional or blue-light filtering) of implanted intraocular lens and survival.

Enrollment: 10,192 patients

Sex: All

Ages: 65+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• The study population consisted of all adult patients (at least 65 years) who underwent bilateral cataract surgery between January 01, 2012 and January 01, 2018 within the University of Pittsburgh Medical Center (UPMC) healthcare system. To be considered bilateral and concomitant, cataract surgery had to be performed on both the left and the right eye within a 365-day period.

Exclusion criteria

• We excluded patients undergoing unilateral cataract surgery, surgery to replace or repair a previously implanted IOL, or bilateral implantation with one Blue-IOL and one Natural-IOL (i.e., mixed IOL transmission properties).

Trial design

10,192 participants in 2 patient groups

Blue-light filtering intraocular lens (IOL)

Description:

Bilateral implantation of blue-filtering intraocular lens. Blue-IOL, in addition to ultraviolet, also impede the transmission of the lower visible blue spectrum between 400 and 500nm.

Treatment:

Device: Blue-light filtering intraocular lens

Conventional intraocular lens (IOL)

Description:

Bilateral implantation of conventional ultraviolet light-blocking intraocular lens

Treatment:

Device: Conventional intraocular lens