Association Between Mitochondrial DNA Content and Risk of Acute Leukemia

Air Force Military Medical University of People's Liberation Army

Status: Completed

Conditions: Lymphoblastic Leukemia in Children

Treatments: Diagnostic Test: Relative copy number of mitochondrial DNA

Study type: Observational

Funder types: Other

Identifiers

NCT03595969

YL2018070101

Details and patient eligibility

About

Compelling epidemiological evidence indicates that alterations of mitochondrial DNA, including mutations and abnormal content of mitochondrial DNA (mtDNA), are associated with the initiation and development of acute lymphoblastic leukemia (ALL).The aim of this study was to explore association between mtDNA content in peripheral blood cells could be used as a risk predictor for ALL.

Enrollment: 300 patients

Sex: All

Ages: Under 16 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 1.histological confirmed chronic lymphocytic leukemia; 2.preparing for chemotherapy; 3.no preoperative anticancer treatment.

Exclusion criteria

• 1.history of other malignancy; 2.blood transfusion within one month or prior bone marrow transplantation; 3.patients who reluctant to sign informed consent.

Trial design

300 participants in 2 patient groups

acute leukemia group

Description:

150 patients were recruited, who have diagnosed with acute leukemia by bone marrow biopsy

Treatment:

Diagnostic Test: Relative copy number of mitochondrial DNA

Control group

Description:

The 50 healthy controls without previous cancer history were recruited from individuals who visited investigator's hospital for physical examination during the same time period as the case enrollment.

Treatment:

Diagnostic Test: Relative copy number of mitochondrial DNA