Association Between Mitochondrial DNA Content and Risk of Coronary Heart Disease

Air Force Military Medical University of People's Liberation Army

Status: Completed

Conditions: Coronary Heart Disease

Study type: Observational

Funder types: Other

Identifiers

NCT02500823

KY20140813-2

Details and patient eligibility

About

Compelling epidemiological evidence indicates that alterations of mitochondrial DNA, including mutations and abnormal content of mitochondrial DNA (mtDNA), are associated with the initiation and development of cardiovascular disease. This study was undertaken to investigate whether mtDNA copy number in peripheral blood cells could be used as a risk predictor for coronary heart disease.

Enrollment: 400 patients

Sex: All

Ages: 18 to 85 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. History of documented myocardial infarction;
2. Prior coronary revascularization intervention (coronary artery bypass graft surgery or percutaneous coronary intervention);
3. The presence of ≥ 50% stenosis in one or more coronary arteries identified during cardiac catheterization;

Exclusion criteria

1. History of malignancy or end-stage renal disease;
2. Blood transfusion within one month or prior bone marrow transplantation
3. Patients who reluctant to sign informed consent

Trial design

400 participants in 2 patient groups

CHD group

Description:

200 consecutive patients were recruited, who have diagnosed with coronary heart disease(CHD) by coronary angiography.

Control group

Description:

The 200 healthy controls without previous CHD history were recruited from individuals who visited investigator's hospital for physical examination during the same time period as the case enrollment.