Association Between Mitochondrial DNA Content and Risk of Gastric Cancer

Air Force Military Medical University of People's Liberation Army

Status: Completed

Conditions: Stomach Neoplasms

Study type: Observational

Funder types: Other

Identifiers

NCT02944539

ZJ20161024

Details and patient eligibility

About

Compelling epidemiological evidence indicates that alterations of mitochondrial DNA, including mutations and abnormal content of mitochondrial DNA (mtDNA), are associated with the initiation and development of gastric cancer.The aim of this study was to explore association between mtDNA content in peripheral blood cells could be used as a risk predictor for gastric cancer.

Enrollment: 600 patients

Sex: All

Ages: 18 to 85 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 1.histological confirmed gastric adenocarcinoma; 2.receiving surgical resection; 3.no preoperative anticancer treatment; 4.alive at least 1 months after surgery.

Exclusion criteria

• 1.history of other malignancy; 2.blood transfusion within one month or prior bone marrow transplantation; 3.patients who reluctant to sign informed consent.

Trial design

600 participants in 2 patient groups

Gastric cancer group

Description:

300 consecutive patients were recruited, who have diagnosed with gastric cancer by biopsy

Control group

Description:

The 300 healthy controls without previous cancer history were recruited from individuals who visited investigator's hospital for physical examination during the same time period as the case enrollment.