Association Between Non-alcoholic Fatty Liver Disease and Iron Status (BAFLA)

Ornit Cohen

Status

Unknown

Conditions

NAFLD - Non Alcoholic Fatty Liver Disease

Treatments

Procedure: blood analysis

Study type

Observational

Funder types

Other

Identifiers

NCT01307254

BAFLA

Details and patient eligibility

About

The investigators hypothesize that low iron storages protects from and down-grades non-alcoholic fatty liver disease.

The aim of the study is to show the association between the severity of Non-alcoholic fatty liver disease to low iron status.

Full description

Patients that will pass a CT scan that includes the abdomen will be asked to participate at our study. These patients will be divided into two groups - with and w/o fatty liver. The severity of fatty liver will be determined using the CT scan (as well as other parameters, such as the size of subcutaneous fat layer). Within 72 hours from the scan, a venous blood test will be taken from the enrolled patients (together with a BMI calculation and a blood pressure measurements). In the blood test we will examine liver functions, iron status etc.

This is a preliminary study that will aid in planning future strategies to treat or even prevent fatty liver (one of the epidemics of our century).

Enrollment

80 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

age>18
BMI>25

Exclusion criteria

pregnancy
unable to sign an informed consent (legally)
known solid/hematological malignancy
hemoglobinopathy or myelodysplastic disease (not including G6PD deficiency)
active or carrier of viral hepatitis
treated a drug the cause fatty liver (eg. amiodarone, tetracyclin, HAART, steroid treatment > 3 months)
consumption of > 120g ethanol per week
primary liver disease (eg. glycogen storage disease)
CRP>20
acute intoxication
surgery in previous 7 days