Association Between Perioperative Platelet Function and Major Adverse Perioperative Events

Hamilton Health Sciences (HHS)

Status

Completed

Conditions

Surgery

Treatments

Procedure: Blood drawn

Study type

Observational

Funder types

Other

Identifiers

NCT00901030

09-066

Details and patient eligibility

About

This study will examine the degree of blood thinning (platelet function) in patients coming for non-cardiac surgery on antiplatelet agents using platelet function tests called thromboelastography (TEG) and platelet mapping assay (PMA) and major cardiac complications that occur any time after surgery (perioperative).

Full description

Patients who have had stents in their coronary arteries (PCI) have to stay on antiplatelet agents to prevent clotting of their stents. These patients often require non-cardiac surgery (NCS) at some stage after their PCI. The rate of major cardiac complications (MACE)in this population is very high and it is unclear why they are at higher risk than the general population. It is possible their antiplatelet is not adequate, or that surgery causes them to be more clot prone. This is a prospective, multicentre observational study.

Enrollment

250 patients

Sex

All

Ages

30 to 85 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

patients between ages 30-85 years old, receiving post-PCI aspirin and/or clopidogrel therapy
patients undergoing non-ambulatory, NCS
patients will have received a bare metal coronary stent within the last 12 months or a drug eluting stent at any time prior to their NCS
the type of surgery has to be such that there are no contra-indictions to remain on an anti-platelet agent
surgeon must agree to keep the patient on at least one anti-platelet agent during the perioperative period

Exclusion criteria