Association Between Plasma D Dimer in Adult CAP and Severity of Inflammatory Response and Survival

Ain Shams University

Status: Enrolling

Conditions: D-dimer

Treatments: Other: Blood Product

Study type: Observational

Funder types: Other

Identifiers

NCT07199530

FAMSU R 135/2025

Details and patient eligibility

About

This is an observational study aiming to investigate the association between elevated plasma D-dimer levels and the inflammatory response, as well as the impact on survival in adult patients with community acquired pneumonia.

the study participants will be subjected to sampling for D dimer and calculation of CURB 65 score. this aims to find the relation between them

Full description

Community-acquired pneumonia (CAP) is a common and potentially life-threatening infection that affects millions of individuals worldwide each year.

D-dimer is a fibrin degradation product that is elevated in many conditions associated with inflammation and coagulation activation, including pneumonia.

This is an observational study including a minimum of 50 patients with CAP

Patients who will be admitted at Chest department, or coming to the outpatient clinic Ain-Shams University Hospitals with CAP and have the following inclusions:

1. age ≥18 years
2. diagnosis of CAP based on clinical symptoms, laboratory findings, and radiological evidence.
3. Did not have any clinical or radiological signs suggesting Covid pneumonia Exclusion criteria Patients with a history of coagulation disorders, cancer, or other chronic diseases, or refusal to participate.

All patients will be subjected to the following: -

1. Full medical history, demographics
2. Thorough clinical examination.
3. laboratory values (including white blood cell count, CRP, and D-dimer), With pre and post sample known precautions (8).
4. Radiological findings (CXR).
5. Severity of illness (based on the CURB-65 score).

Enrollment: 50 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients who will be admitted at Chest department, or coming to the outpatient clinic Ain-Shams University Hospitals with CAP and have the following inculsions:

  1. age ≥18 years
  2. diagnosis of CAP based on clinical symptoms, laboratory findings, and radiological evidence.

Exclusion criteria

• Patients with a history of coagulation disorders, cancer, or other chronic diseases, or refusal to participate.
• patients who have any clinical or radiological signs suggesting Covid pneumonia.

Trial design

50 participants in 1 patient group

only one group which will include patients with CAP to take a blood samplr for d dimer

Treatment:

Other: Blood Product