Association Between Postoperative Administration of L-Arginine and CSA-AKI

Air Force Military Medical University of People's Liberation Army

Status: Enrolling

Conditions: Acute Kidney Injury

Treatments: Drug: L-Arginine hydrochloride

Study type: Observational

Funder types: Other

Identifiers

NCT06248359

KY20232170-C-1

Details and patient eligibility

About

To investigate the association between the the early administration of L-Arginine after CPB-assisted cardiac surgery and the incidence of CS-AKI in adult patients. To test if it can reduce the incidence of post-operative AKI.

Enrollment: 7,000 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• adult patients (over 18 years)
• underwent CPB assisted cardiac surgery
• admitted to ICU

Exclusion criteria

• congenital heart disease
• underwent deep hypothermic circulatory arrest (DHCA)
• with glomerular filtration rate (eGFR) below 30 mL/min/1.73 m²

Trial design

7,000 participants in 2 patient groups

Arginine Use

Description:

At least one dose of L-arginie was administered in the early postoperative stage

Treatment:

Drug: L-Arginine hydrochloride

Without Arginine

Description:

No L-arginie was administered