Association Between Pre-op Non-Selective Beta-Blockers and Hepatocellular Carcinoma Recurrence Post-Liver Transplant

Asan Medical Center

Status: Completed

Conditions: Hepatocellular Carcinoma Recurrent; Hepatocellular Carcinoma

Treatments: Drug: Non-Selective Beta-Adrenoreceptor Agonists for Systemic Use

Study type: Observational

Funder types: Other

Identifiers

NCT06233708

2023-0713

Details and patient eligibility

About

The goal of this observational study is to investigate the effect of non-selective beta-blocker (NSBB) on the recurrence of hepatocellular carcinoma (HCC) following liver transplantation in patients who underwent liver transplantation (LT) for treating hepatocellular carcinoma.

The main question[s] it aims to answer are:

• Is the usage of non-selective beta-blocker associated with decreased recurrence of hepatocellular carcinoma following liver transplantation?
• Is the usage of non-selective beta-blocker associated with all-cause mortality following liver transplantation?

Researchers will compare the NSBB group, including patients who received non-selective beta-blocker therapy for at least 30 consecutive days within 3 months prior to liver transplantation more than 30 days prior, with the control group to to see if non-selective beta-blocker treatment is associated with decreased recurrence of hepatocellular carcinoma following liver transplantation.

Enrollment: 2,092 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult patients
• Underwent liver transplantation for treating hepatocellular carcinoma
• Between Jan. 2008 - May. 2022

Exclusion criteria

• Pediatric patients (Age under 18 years)
• Re-transplantation
• Multi-organ transplantation

Trial design

2,092 participants in 2 patient groups

NSBB group

Description:

The NSBB group was defined as those who received NSBBs for at least 30 consecutive days within the 3 months prior to LT.

Treatment:

Drug: Non-Selective Beta-Adrenoreceptor Agonists for Systemic Use

Control group

Description:

Those who did not meet the above criteria were classified as the control group.