Association Between Surgical Timing and Route of Total Hysterectomy After LEEP and Perioperative Risk in Patients With Cervical HSIL

University of Electronic Science and Technology of China (UESTC)

Status: Completed

Conditions: High-Grade Squamous Intraepithelial Lesions

Treatments: Procedure: surgical timing and operation path

Study type: Observational

Funder types: Other

Identifiers

NCT06325592

REHSIL2023V1.1

Details and patient eligibility

About

This study aimed to analyze perioperative information in patients with high-grade squamous intraepithelial lesion (HSIL) undergoing total hysterectomy (TH), offering insights into optimal surgery timing, selecting the operation path, and enhancing surgical operation details.

Enrollment: 826 patients

Sex: Female

Volunteers: No Healthy Volunteers

Inclusion criteria

• patients were confirmed with HSIL through pathology at our hospital or another tertiary facility, with additional confirmation via pathological consultation at our facility;
• LH or abdominal hysterectomy (AH) +/- bilateral fallopian tube or bilateral adnexectomy was performed after LEEP;
• the patient had no history of systemic malignancies.

Exclusion criteria

• severe medical and surgical complications;
• an extensive or subextensive hysterectomy was performed;
• surgical removal scope involving tissues (such as lymph nodes) or organs (such as the appendix) other than the uterus, ovaries, and fallopian tubes;
• fever symptoms within the last month;
• incidence of pelvic and abdominal infections, vaginitis, or similar conditions within the past month.

Trial design

826 participants in 5 patient groups

group 1

Description:

patients underwent laparoscopic hysterectomy within 3 days after LEEP

Treatment:

Procedure: surgical timing and operation path

group 2

Description:

patients underwent abdominal hysterectomy within 3 days after LEEP

Treatment:

Procedure: surgical timing and operation path

group 3

Description:

patients underwent laparoscopic hysterectomy 4 weeks after LEEP

Treatment:

Procedure: surgical timing and operation path

group 4

Description:

underwent abdominal hysterectomy 4 weeks after LEEP

Treatment:

Procedure: surgical timing and operation path

control group

Description:

Patients who underwent laparoscopic hysterectomy (LH) due to benign gynecological diseases were included in the control group.