Association Between Telomere Length and Cardiac Dysfunction

Air Force Military Medical University of People's Liberation Army

Status: Completed

Conditions: Cardiac Toxicity; Acute Leukemia; Childhood Cancer

Treatments: Diagnostic Test: Relative telomere length

Study type: Observational

Funder types: Other

Identifiers

NCT04409379

YL2019100602

Details and patient eligibility

About

Compelling epidemiological evidence indicates that alterations of relative telomere length (RTL) are associated with cardiac dysfunction caused by chemotherapy in children with acute leukemia (AL).The aim of this study was to explore association between RTL content in peripheral blood cells could be used as a risk predictor for severity of cardiac damage.

Enrollment: 300 patients

Sex: All

Ages: 1 to 16 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• 1. histological confirmed acute leukemia; 2. Preparing for chemotherapy;

Exclusion criteria

• 1.history of other malignancy; 2.blood transfusion within one month or prior bone marrow transplantation; 3.patients who reluctant to sign informed consent.

Trial design

300 participants in 1 patient group

acute leukemia group

Description:

300 patients were recruited, who have diagnosed with acute leukemia by bone marrow biopsy

Treatment:

Diagnostic Test: Relative telomere length