Association Between Tendon-related Transcription Factor and Ultrasound Images and Shoulder Function

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National Taiwan University




Rotator Cuff Tendinosis
Rotator Cuff Tears

Study type


Funder types




Details and patient eligibility


The purpose of this project is to extract effusions and damaged tendons during tendon repair therapy in patients with tendon tears. Then, we would analyze tendon-related transcription factors from histology and cytology, and compare changes in tendon with ultrasound images. Helps to understand the mechanism of tendon lesions.

Full description

According to past studies, it is often observed that changes in extracellular matrix, growth factors, and cytokines in degenerative tendons, indicating that the tendon is constantly changing. This change will in turn produce a change in the morphology of the tendon tissue in the ultrasound image. However, there have been few studies in the past literature on the correlation between constant changes in tendon-specific transcription factors and characterization on clinical ultrasound images. Therefore, the purpose of this project is to extract the effusion and damaged tendon while performing tendon repair therapy in patients with tendon tears, and to analyze the tendon-related transcription factors from histology and cytology to understand the changes in tendon homeostasis. At the same time, the interpretation of clinical ultrasound images was combined to establish the relationship between the biochemical factors of the cell tissues of chronic tendon lesions and the clinical ultrasound image. This study will help us to understand the mechanism of chronic tendinopathy.


20 estimated patients




20+ years old


No Healthy Volunteers

Inclusion criteria

  • age older than 20 y
  • shoulder pain more than 3 months and Visual Analogue Scale (VAS) >4
  • shoulder tendon defect on ultrasound images

Exclusion criteria

  • diagnosis of cervical radiculopathy or other central or peripheral neuropathy
  • rheumatoid arthritis or other autoimmune diseases
  • have received any shoulder joint injection within three months
  • tumor or systematic inflammation

Trial contacts and locations



Central trial contact

Chao Yuan-Hung, PhD

Data sourced from

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