Association Between the Results of Specific Genetic Tests and the Efficacy of Targeted Therapies in Patients

Hunan Province Tumor Hospital

Status: Completed

Conditions: Non-small Cell Lung Cancer

Study type: Observational

Funder types: Other

Identifiers

NCT05450081

ART

Details and patient eligibility

About

Our study aimed to evaluate the correlation between test reagent specific gene test results and the efficacy of relevant targeted drugs in patients with non-small cell lung cancer, and to support the continued registration of test reagents.

Enrollment: 140 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 1)≥18，advanced non-small cell lung cancer confirmed by histopathology, and were previously or currently treated with gefitinib tablets (as the first-line treatment) or osimertinib (first-generation TKI resistance treatment) or crizotinib capsules monotherapy were evaluated for efficacy.
• 2. Able to provide FFPE samples with a storage life of 5 years: Large specimen 5 pieces in each case; 10 puncture specimens in each case

Exclusion criteria

• 1. Pathological evaluation of the tissue sample has too few tumor cells (total number of tumor cells >20%);
• 2. Combination therapy with chemotherapy/radiotherapy/other targeted drugs/immunotherapy drugs;
• 3. Maintenance treatment when the disease does not progress after other anti-tumor treatments.