Association Between Vitamin D Deficiency and Inflammatory Bowel Disease

Assiut University

Status: Not yet enrolling

Conditions: Inflammatory Bowel Diseases

Treatments: Diagnostic Test: Serum 25(OH)D (Vitamin D3), C- reactive protein, Erthrocyte sedimentation rate

Study type: Observational

Funder types: Other

Identifiers

NCT07259603

ADIBD

Details and patient eligibility

About

Crohn's disease (CD) and ulcerative colitis (UC) are two major types of inflammatory bowel disease (IBD) that are identified by different clinical, endoscopic, pathological, and radiologic diagnostic methods.

In the past few years, the incidence of inflammatory bowel disease has been increasing worldwide, with the incidence of UC being higher than that of CD.

Vitamin D is a fat-soluble vitamin that is produced in the skin by a UV-dependent reactionand then hydroxylated by the kidneys and liver, and is converted to its active form, 1,25-dihydroxyvitamin D.

Vitamin D deficiency is common throughout the world and its deficiency rates ranging from 30 to 50% have been reported.

Several studies have shown the role of vitamin D as a regulator of the immune system and its inhibitory function incellular immunity and production of pro-inflammatory cytokines that play a major role in autoimmune diseases.

In some human studies, the link between vitamin D levels and the disease severity of IBD has been shown, but it is not clear whether lack of vitamin D is the cause or consequence.

In this study, we aimed to investigate the relationship between inflammatory bowel disease and itsflare-up with serum levels of vitamin D

Enrollment: 100 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adults aged ≥18 years
• Diagnosed with crohn's and ulcerative colitis
• Regular follow-up in IBD clinic
• Recent vitamin D and disease activity assessment (within 1 month)

Exclusion criteria

• Current vitamin D supplementation(>1000IU/day)

  • History of malabsorption syndromes (e.g.,celiac disease)
  • Chronic kidney or liver disease
  • Pregnancy

Trial design

100 participants in 1 patient group

patients diagnosed with Crohn's disease (CD) and ulcerative colitis (UC)

Description:

Adults aged ≥18 years, diagnosed with Crohn's disease (CD) and ulcerative colitis (UC), and on regular follow-up in the IBD clinic, are followed up for recent vitamin D and disease activity assessment (within 1 month)

Treatment:

Diagnostic Test: Serum 25(OH)D (Vitamin D3), C- reactive protein, Erthrocyte sedimentation rate