Association Between Vitamin D Deficiency and Preeclampsia: A Case Control Study

Ain Shams Maternity Hospital

Status: Completed

Conditions: Pre-Eclampsia

Study type: Observational

Funder types: Other

Identifiers

NCT02677233

vid-20

Details and patient eligibility

About

To find out if lower levels of vitamin D is more prevalent in preeclamptic women

Enrollment: 90 patients

Sex: Female

Ages: 18 to 35 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Parity: primigravida.
• Age: 18 - 35 years.
• Singleton pregnancy.
• Gestational age: 36-40 weeks.
• No past history of any medical disorder and with no other medical complications during pregnancy

Exclusion criteria

• Women with preexisting medical conditions like rheumatoid arthritis, thyroid, hepatic or renal failure, metabolic bone disease, diabetes mellitus, malabsorption and lupus.
• History of intake of medications influencing bone, vitamin D or calcium metabolism e.g. antiepileptic, theophylline, antitubercular drugs in the last 6 months.
• Women with multiple pregnancy.
• Women with congenital fetal malformation.
• Women with known thrombophilia

Trial design

90 participants in 2 patient groups

preeclamptic group

Description:

1. Blood pressure: greater than or equal to 140 mmHg systolic or greater than or equal to 90 mmHg diastolic on two occasions at least 4 hours apart after 20 weeks of gestation (Roberts et al., 2013). 2. Proteinuria: protein/creatinine ratio greater than or equal to 0.3 3. In the absence of proteinuria, a new-onset hypertension with new onset of the following: * thrombocytopenia: platelet count less than 100.000/microliter * renal insufficiency: serum creatinine greater than 1.1 mg/dl * impaired liver function: elevated concentration of liver transaminases * pulmonary edema * cerebral or visual symptoms * Severe right upper quadrant or epigastric pain unresponsive to medication.

non preeclamptic group

Description:

All are normotensive with blood pressure \<140/90 with no proteinuria.