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Association of Air Quality and Myocardial Infarction

M

Medical University of Graz

Status

Completed

Conditions

Acute Myocardial Infarction

Treatments

Other: air pollution

Study type

Observational

Funder types

Other

Identifiers

NCT02880436
28-292ex15/16

Details and patient eligibility

About

Besides classical cardiovascular risk factors such as smoking, obesity, elevated cholesterol levels and diabetes there are also acute factors potentially triggering acute coronary events. The impact of various substances and air pollution are described.

Particulate matter, especially with small particle size (<2.5µm) has been shown to have a positive correlation with myocardial infarctions. However, other studies failed to show this correlation.

With respect to nitric oxydes the majority of published studies detected a significant correlation with myocardial infarction, too, although a highly ranked publication failed to show the same result. In addition data on the impact of sulfur dioxide and carbon monoxide concentration on cardiac events is very heterogeneous.

Published data indicates additive effects of age and other epidemiological variables suggesting the need of a multivariate analysis.

The rationale of the study is to test if the above mentioned air pollution factors have a significant and independent impact on the incidence of myocardial infarctions

Full description

The analysis will be performed in a well characterized patient cohort of 12.000 myocardial infarctions within 10 years being invasively diagnosed at the catheterisation centers of the styrian capital Graz.

Enrollment

12,000 estimated patients

Sex

All

Ages

18 to 99 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

  • myocardial infarction being confirmed or treated in the cathlab

Exclusion criteria

  • none

Trial contacts and locations

1

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Data sourced from clinicaltrials.gov

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