Association of Anticholinergic Burden With Onset of Delirium in Older Adults With Alzheimer Dementia:

Gulhane Training and Research Hospital

Status: Unknown

Conditions: Alzheimer Disease; Delirium; Anticholinergic Adverse Reaction

Treatments: Drug: Anticholinergic burden

Study type: Observational

Funder types: Other

Identifiers

NCT05055895

2020-383

Details and patient eligibility

About

Drugs with anticholinergic properties are commonly prescribed to older persons despite growing evidence of their significant adverse effects. However, limited data are available concerning their contribution to time of onset of delirium. This study aimed to determine the potential association of higher anticholinergic burden to early-onset of delirium superimposed dementia in the older adult.

Enrollment: 450 estimated patients

Sex: All

Ages: 65+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• 65 years and older and diagnosis or fellow-up of Alzhemier dementia in outpatient clinic.

Exclusion criteria

• The patients with a history of other than Alzhemier dementia or neurodegenerative disease (epilepsy, multiple sclerosis, Parkinson disease, etc.), terminal illness (malignancy, advanced organ failure) were excluded.

Trial design

450 participants in 2 patient groups

early onset deliryum on dementia

Description:

It was earlier than The median time of onset of delirium superimposed dementia

Treatment:

Drug: Anticholinergic burden

Delirium on dementia (normal)

Description:

It was equal or later than The median time of onset of delirium superimposed dementia

Treatment:

Drug: Anticholinergic burden