Association of Apical Periodontitis With Chronic Kidney Disease

Postgraduate Institute of Dental Sciences Rohtak

Status: Completed

Conditions: Chronic Kidney Diseases; Periapical Lesions

Treatments: Biological: levels of CKD markers, Oral health status, apical periodontitis; Biological: systemic inflammatory marker, Oral health status, apical periodontitis

Study type: Observational

Funder types: Other

Identifiers

NCT05818657

Dr. Jyoti Lamba

Details and patient eligibility

About

This investigation is aimed to assess the prevalence and severity of apical periodontitis (AP) in different stages of CKD patients and its impact on the systemic (nutritional and inflammatory) markers was compared to healthy individuals.

Full description

105 CKD patients (35 early (EG), 35pre-dialysis (PDG) and 35 hemodialysis (HDG)groups and 105 age and gender matched healthy controls were assessed for prevalence and severity of apical periodontitis and oral disease burden . Inflammatory (hsCRP and ferritin) and nutritional (urea and creatinine) markers were estimated and eGFR was calculated for the study population. Logistic regression was used to determine the possible association between CKD and AP in study population and Linear regression was performed to evaluate the possible association between systemic markers and endodontic burden (EB) in experimental group.

Enrollment: 210 patients

Sex: All

Ages: 18 to 80 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Known patient of CKD Stages 1,2,3,4 & 5 with estimated glomerular filtration rate [eGFR; MDRD] with mature permanent teeth.
• > 18 years
• > 8 natural teeth.
• Complete medical & dental history including panoramic radiographs of maxilla & mandible

Exclusion criteria

• Patients having systemic disorders other than CKD (eg HIV, Diabetes mellitus, Coronary heart disease, history of secondary hyperparathyroidism).
• Pregnancy, lactation & contraceptives.
• Systemic conditions that contra indicates dental treatment.
• Use of antibiotics & anti-inflammatory in last 3 months
• Need for antibiotic prophylaxis.
• Hepatitis C and B virus.
• Patients on steroids.

Trial design

210 participants in 2 patient groups

Group-A CKD patients

Description:

Prevalence of apical periodontitis will be checked and non-surgical root canal treatment will be given to the patients with apical periodontitis and change in PAI score, eGFR \& Systemic markers will be checked

Treatment:

Biological: levels of CKD markers, Oral health status, apical periodontitis

Group-B Healthy individuals

Description:

Prevalence of apical periodontitis will be checked and non-surgical root canal treatment will be given to the patients with apical periodontitis and change in PAI score, eGFR \& Systemic markers will be checked

Treatment:

Biological: systemic inflammatory marker, Oral health status, apical periodontitis