Association of Biomarkers and Gastric Antral Motility Index With Feeding Intolerance in Critically Ill Patients

Jilin University

Status

Invitation-only

Conditions

Critically Ill Patients Who Are Not Allowed to Eat Orally But Can Initiate Enteral Nutrition Within 48 Hours of ICU

Treatments

Other: Not applicable- observational study

Study type

Observational

Funder types

Other

Identifiers

NCT07178626

BGM-FI

Details and patient eligibility

About

When the subjects are admitted to the department, the researchers will monitor potential biomarkers of gastrointestinal injury before administering enteral nutrition (a small amount of blood is drawn, serum is separated by centrifugation, and the serum sample is frozen for final centralized biomarker detection), and measure the antral movement index under ultrasound (300ml of warm water is injected into the stomach before measurement, and then the antral movement is observed for 6 minutes) Then, monitor whether the patient has developed feeding intolerance within 7 days of the ICU

Enrollment

160 estimated patients

Sex

All

Ages

18+ years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Age ≥18 years
Presence of one or more organ system failures within 24 hours of ICU admission (SOFA score ≥2)
Expected ICU stay >48 hours
Inability to take oral nutrition
No contraindications to enteral nutrition (EN)

Exclusion criteria

Patients who have already received enteral nutrition prior to gastric antral motility measurement or biomarker collection
Receiving palliative care with expected death within 48 hours
Pregnancy
Participation in another clinical trial