Association of Bisphenol A,Paraben Exposure and Type 2 Diabetes

Cairo University (CU)

Status: Enrolling

Conditions: Type2 Diabetes; Bisphenol A

Treatments: Device: HPLC

Study type: Interventional

Funder types: Other

Identifiers

NCT05177250

bisphenol A,paraben, type 2DM

Details and patient eligibility

About

The aim of this study is to evaluate the association between BPA , paraben levels and type 2 DM patients

Full description

The first phase of the study will include a questionnaire :

• The cases and control will be asked about demographic information such as residence, age, education, and occupation.
• History of discovery of diabetes.
• Exposure to products and materials such as polycarbonate plastics, cosmetics and beverages containing bisphenol A and paraben and it will be evaluated through exposure sheet through asking about dietary exposure, Environmental exposure and medical exposure.

Then clinical evaluation including:

• Full clinical examination will be performed for cases and control.
• Anthropological data:

their weights, heights and waist circumference will be measured. The body mass index (BMI) will be calculated by weight (kg)/height (m)2 formula.

• Investigations: routine and specific investigation as blood glucose level, HbA1c and lipid profile.
• Urine specimens will be collected in clean, glass containers will labeled with the subject identification number. Turbid sample or those containing blood will be excluded.
• All specimens will be stored frozen below 20 degree centigrade.
• Urine samples will be analyzed by High Performance liquid chromatograph (HPLC) to detect bispenol A and parabens levels.

Enrollment: 100 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. Adult patients ( 18 y or elder).
2. Type 2 DM

Exclusion criteria

• Type 1 DM
• Less than 18 y
• History of chronic diseases such as liver failure, cardiac patients......etc

Trial design

Primary purpose: Screening

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

---

100 participants in 2 patient groups

Case group

Other group

Description:

50 cases with type 2 DM.

Treatment:

Device: HPLC

Control group

Other group

Description:

50 subjects not diabetics.

Treatment:

Device: HPLC