Association of Cephalosporin Resistance and Surgical Site Infections in Patients Undergoing Pancreaticoduodenectomy

Helsinki University Central Hospital (HUCH)

Status: Completed

Conditions: Surgical Site Infection; Pancreaticoduodenectomy; Biliary Tract Infection Bacterial

Treatments: Procedure: Preoperative biliary drainage

Study type: Observational

Funder types: Other

Identifiers

NCT05581017

HUS-115-2020-56

Details and patient eligibility

About

Preoperative biliary drainage predisposes the bile to be contaminated with bacteria of the duodenum. These bacteria colonizing the bile are a potential source for surgical site infections after pancreaticoduodenectomy and many international guidelines recommend the use of cephalosporines as microbial prophylaxis before surgery. The aim of this study was to assess the incidence of bacteria in bile, their resistance profiles and association to surgical site infections in relation to timing of surgery after preoperative biliary drainage in order to better guide antibiotic use.

Enrollment: 376 patients

Sex: All

Ages: 18 to 100 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• All patients undergoing pancreaticoduodenectomy between May 23rd 2016 to October 29th 2020

Exclusion criteria

• Patients without intraoperative biliary culture
• Patients with unknown date of preoperative biliary culture

Trial design

376 participants in 3 patient groups

No PBD

Description:

Patients without preoperative biliary drainage before pancreaticoduodenectomy

PBD < 2 months

Description:

Patients who had undergone preoperative biliary drainage and the pancreaticoduodenectomy was in 2 months after the drainage.

Treatment:

Procedure: Preoperative biliary drainage

PBD ≥ 2 months

Description:

Patients who had undergone preoperative biliary drainage and the pancreaticoduodenectomy was at 2 months or later after the drainage.

Treatment:

Procedure: Preoperative biliary drainage