Association of Comorbidities With COVID19

Assiut University

Status: Unknown

Conditions: COVID19

Treatments: Diagnostic Test: realtime PCR

Study type: Observational

Funder types: Other

Identifiers

NCT04459390

COVID19

Details and patient eligibility

About

Association of Comorbidities with unfavorable COVID19 outcomes as admission to intensive care, invasive ventilation or death.

Full description

COVID19 is a new emerging, rapidly disseminating disease that consuming most of resources of efficient healthcare systems, and several hospitals, worldwide, are currently experiencing a shortage of ICU beds for critically ill patients with COVID-19 pneumonia.

A risk stratification based on clinical, radiological and laboratory parameters seems necessary in order to better identify those patients who may need hospital and/or ICU admission.

One of the most alarming clinical parameters in general is the presence comorbidities. The underlying diseases including hypertension, diabetes mellitus, respiratory system disease and cardiovascular disease, may be risk factors for severe COVID-19 patients with adverse outcomes compared with non-severe patients. Obesity is also a risk factor for COVID-19 severity with increased need to mechanical ventilation.

Chronic diseases share several features with infectious disorders, such as the proinflammatory state, and the attenuation of the innate immune response which may be linked etiologically to its pathogenesis.

Aim of the study:to assess the impact of comorbidities in patients with diagnosis of Covid-19 on outcome, in order to find the predictors of prolonged hospital stay, need for ICU admission or poor outcome

Enrollment: 100 estimated patients

Sex: All

Volunteers: No Healthy Volunteers

Inclusion criteria

• Diagnosis of Covid-19 test positive; hospitalized subjects; both sexes.

Exclusion criteria

• no exclusion criteria

Trial design

100 participants in 2 patient groups

COVID19 with comorbidities

Description:

Patients with COVID19 with at least one of the following comorbidities: 1. Hypertension 2. Diabetes 3. Cardiovascular disease 4. Chronic pulmonary disease 5. Obesity 6. Chronic liver disease 7. Chronic kidney disease 8. Collagen vascular disease 9. Autoimmune disease 10. Malignancy

Treatment:

Diagnostic Test: realtime PCR

COVID19 without comorbidities

Description:

Patients with COVID19 without any of the previously mentioned comorbidities

Treatment:

Diagnostic Test: realtime PCR