Association of Continuous Renal Replacement Therapy With Mortality and Length of Stay in Critically Burned Patients (CRRT-BURN)

Pinar Timur Tasci

Status: Completed

Conditions: Severe Burns; Acute Kidney Injury; Critical Illness

Study type: Observational

Funder types: Other

Identifiers

NCT07195565

DrLutfiKirdarTRH-ANES-PTT-01

Details and patient eligibility

About

This retrospective observational study aims to investigate the clinical outcomes of critically ill burn patients who underwent continuous renal replacement therapy (CRRT). Primary endpoints include the evaluation of RIFLE criteria, timing of CRRT initiation, and overall survival. Secondary endpoints consist of comorbidity status, requirement for mechanical ventilation, inotropic support, and hospital length of stay among non-survivors.

Full description

Severe burn injury is frequently complicated by acute kidney injury (AKI), which is associated with high morbidity and mortality in intensive care settings. Continuous renal replacement therapy (CRRT) is often required in this patient population; however, the prognostic factors influencing survival remain incompletely defined.

In this retrospective study, we analyzed critically ill burn patients who required CRRT. The primary outcomes were the RIFLE classification at the time of CRRT initiation, the timing of therapy initiation, and patient survival. The secondary outcomes included the presence of comorbidities, the need for mechanical ventilation, inotropic support, and length of hospital stay in non-survivors.

By systematically evaluating these clinical parameters, the study aims to clarify the prognostic impact of CRRT in burn patients and to contribute evidence for optimizing the management of acute kidney injury in this critically ill population.

Enrollment: 238 patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Patients aged 18 years and older
• Admitted to and treated in the Burn Intensive Care Unit

Exclusion criteria

• Patients with an ICU stay of less than 24 hours
• Patients younger than 18 years
• Patients with known chronic kidney disease or history of kidney transplantation
• Patients admitted with toxic epidermal necrolysis (TEN)
• Patients with estimated glomerular filtration rate (eGFR) ≤ 15 mL/min/1.73m² at admission