Association of Dysbiosis and Immune Response in Bronchiolitis in Under 12 Months -Old Infants (BRONCHOBIOTE)

Assistance Publique - Hôpitaux de Paris

Status: Enrolling

Conditions: Bronchiolitis

Treatments: Other: Sampling

Study type: Observational

Funder types: Other

Identifiers

NCT06161285

2023-A01688-37 (Other Identifier)

APHP231177

Details and patient eligibility

About

Acute bronchiolitis is a common disease in children under the age of two, caused mainly by the respiratory syncytial virus (RSV). Furthermore, given the same medical history, it is still very difficult to predict the course and severity of the infection at the onset of symptoms, Some studies have highlighted the importance of the microbiota (intestinal, oral or nasopharyngeal) and of the immune response to RSV in children, We will include 80 children under 2 years old with hospitalized bronchiolitis and non-hospitalized bronchiolitis. Oral, nasal and stool samples will be taken to study the various microbiota in search of dysbiosis. A capillary blood sample will be taken for immune studies.

Enrollment: 120 estimated patients

Sex: All

Ages: 1 day to 12 months old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Infants <12 months
• With bronchiolitis during RSV epidemic season
• No chronic illness
• No bronchiolitis medical history
• Signed consent from parents or legal guardians

Exclusion criteria

• Chronic respiratory illness
• Medical history of bronchiolitis or newborn asthma
• Treatment with immunosuppressants
• Patient with no social security affiliation

Trial design

120 participants in 3 patient groups

Severe bronchiolitis

Description:

venous blood samples. Buccal, nasopharyngeal and rectal swabs

Treatment:

Other: Sampling

Non-hospitalized bronchiolitis

Description:

Capillary blood samples. Buccal, nasopharyngeal and rectal swabs

Treatment:

Other: Sampling

Bronchiolitis ihospitalized in ICU

Description:

Capillary blood samples. Buccal, nasopharyngeal and rectal swabs