Association of Genetic Variants With Myopia

Beijing Visionly Plus Eye Hospital

Status: Enrolling

Conditions: Myopia

Treatments: Genetic: Oral swab DNA analyzed for myopia-related gene variants

Study type: Observational

Funder types: Other

Identifiers

NCT07030153

Precvision202501

Details and patient eligibility

About

This study aims to identify genetic factors linked to myopia, including those that influence a person's risk of developing it and how quickly it progresses (like changes in eye length). It will also examine how different treatments-such as low-dose atropine drops, orthokeratology lenses, specialized glasses, and increased outdoor time-interact with these genes. Finally, the research will develop a genetic risk score to help tailor personalized myopia prevention and treatment plans.

Enrollment: 1,000 estimated patients

Sex: All

Ages: 6 to 18 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Age 6-18 years.
• Any Spherical equivalent refraction (SER)
• Parental consent for genetic testing.

Exclusion criteria

• Suspected genetic syndromes (e.g., Stickler, Marfan).
• Other eye diseases (e.g., glaucoma, cataracts, retinal abnormalities, strabismus).
• Prior refractive surgery

Trial design

1,000 participants in 2 patient groups

Genetic and myopia onset

Description:

Identify genetic variants (GWAS/WES) associated with: * Myopia onset risk (high-risk SNPs ). * Myopia progression rate (e.g., axial elongation/year).

Treatment:

Genetic: Oral swab DNA analyzed for myopia-related gene variants

Genetic and myopia intervention

Description:

Evaluate gene-intervention interactions for: * Low-dose atropine (0.01%, 0.05%). * Orthokeratology. * Defocus-incorporated spectacles. * Outdoor/sunlight exposure (≥2 hours/day).

Treatment:

Genetic: Oral swab DNA analyzed for myopia-related gene variants