Association of Haptoglobin 2-2 With Postoperative Delirium

Sun Yat-sen University

Status: Withdrawn

Conditions: Postoperative Delirium

Study type: Observational

Funder types: Other

Identifiers

NCT03392480

S2017-096-02

Details and patient eligibility

About

Patients with major orthopedic surgery will be recruited. Participants will be monitored for delirium after surgery. Participants' blood will be harvested for the determination of haptoglobin types, levels of oxidative stress and inflammation. Investigators will then analyze the data to see if haptoglobin 2-2 type is associated with an increased postoperative delirium, inflammation and oxidative stress.

Sex: All

Ages: 45+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• American Society of Anesthesiologists physical status I to III class for major orthopedic surgery (hip or knee replacement or spinal surgery)
• No psychological and psychiatric history and presentation before surgery
• No major organ dysfunction or failure

Exclusion criteria

• Anemia (hemoglobin < 100 g/l) preoperatively.
• Requires > 4 units of allogeneic red blood cell transfusion during the surgery
• Using steroids or anti-psychological and anti-psychiatric drugs. A small dose of steroid for postoperative anti-nausea/vomiting is allowed and will not be considered as a indication for exclusion.
• Can not cooperate with the study
• History of bleeding
• BMI < 18 or > 30
• History of hemoglobin metabolism disorder

Trial design

0 participants in 4 patient groups

Adult non-haptoglobin 2-2 group

Description:

Patients are 45 to 65 years old.

Adult haptoglobin 2-2 group

Description:

Patients are 45 to 65 years old.

Elder non-haptoglobin 2-2 group

Description:

Patients are elder than 65 years.

Elder haptoglobin 2-2 group

Description:

Patients are elder than 65 years.