Association of HMOs and Allergic Manifestations

Chulalongkorn University

Status: Unknown

Conditions: Human Milk Oligosaccharides, Allergic Manifestation

Treatments: Procedure: milk collection

Study type: Observational

Funder types: Other

Identifiers

NCT03256370

HMOs

Details and patient eligibility

About

Compare the HMO composition in breast milk of infants with allergic manifestation (atopic dermatitis and food allergy) in the first 3 years of life, healthy infants with allergic mother and healthy infants with non-allergic mother.

Full description

• Parents of breast-fed infant from general pediatric clinic and allergy clinic of King Chulalongkorn Memorial Hospital were approached for informed about the research and ask to join this project
• After completed informed consent, demographic data was collected and filled in case record form
• Milk of mother in both allergic and control groups were collected 60 ml then transferred to freeze at -80oc to for human milk oligosaccharide analysis

Enrollment: 150 estimated patients

Sex: All

Ages: Under 2 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

1. mothers with breast-fed infant with or without allergic manifestation
2. Intend to participate for follow up and sign consent to participate in the study

Exclusion criteria

1. Mothers with any medical illness or high risk infant pregnant
2. Infants with disease which affected allergic disease
3. No inform consent
4. Anything in the opinion of the investigator that would prevent children from completing the study

Trial design

150 participants in 3 patient groups

Infants with allergic diseases

Description:

allergic disease : atopic dermatitis or food allergy

Treatment:

Procedure: milk collection

Healthy infants with atopic mothers

Description:

atopic mothers : mothers with asthma or allergic rhinitis or allergic dermatitis (diagnosed by doctors)

Treatment:

Procedure: milk collection

Healthy infants with non-atopic mothers.

Description:

non-atopic mothers : mothers without history of asthma or allergic rhinitis or allergic dermatitis

Treatment:

Procedure: milk collection