Association of Intraoperative Renal Regional Oxygen Saturation and Acute Kidney Injury

Seoul National University

Status: Completed

Conditions: Liver Transplant; Complications; Renal Injury

Treatments: Device: Near-infrared spectroscopy

Study type: Interventional

Funder types: Other

Identifiers

NCT03877133

1901-087-100

Details and patient eligibility

About

This study is a prospective observational study of a single cohort of the patients who will undergo a scheduled living donor liver transplantation.

The investigators attempt to evaluate the association of intraoperative renal regional oxygen saturation and acute kidney injury in patients undergoing living donor liver transplantation. Near-infrared spectroscopy sensor will be attached to the skin near bilateral kidney areas in all patients and renal regional oxygen saturation will be monitored during the operation. Renal regional oxygen saturation (rSO2) of the patients who developed acute kidney injury postoperatively will be compared with rSO2 of the patients who did not.

Full description

Acute kidney injury is a frequent complication after liver transplantation, which is related to poor prognosis and longer hospital stay. There is no sensitive or specific marker for predicting postoperative acute kidney injury, although studies of the biomarkers have shown promising results.

Near-infrared spectroscopy is a non-invasive and real-time monitoring device for regional oxygen saturation measurement. Previous studies revealed that it could be applied to the skin near the kidney and be used to monitor renal regional oxygen saturation.

Therefore, in this study, the investigators will apply near-infrared spectroscopy around kidney area to measure real-time renal regional oxygen saturation during liver transplantation surgery and investigate the association between the intraoperative renal regional oxygen saturation and the development of post-transplant acute kidney injury.

Enrollment: 50 patients

Sex: All

Ages: 20+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Adult patients scheduled to undergo elective living donor liver transplantation
• Patients who provided written informed consent

Exclusion criteria

• Missing preoperative serum creatinine value
• Underlying kidney disease, such as hepatorenal syndrome, chronic kidney disease
• History of unilateral or bilateral nephrectomy
• Patients who died within 48 hours immediately after surgery
• Any skin problem at the attachment site of regional oxygen saturation probe

Trial design

Primary purpose: Prevention

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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50 participants in 1 patient group

Regional oxygen saturation group

Other group

Description:

Near-infrared spectroscopy application to the skin near the kidney

Treatment:

Device: Near-infrared spectroscopy