Association of Intravenous Ketamine With Thoracic Epidural Analgesia: Effects on Pain and Respiratory Function Following Thoracotomy.

Public Assistance-Hospitals of Marseille (AP-HM)

Status

Terminated

Conditions

Thoracotomy

Treatments

Drug: ketamine

Drug: placebo

Study type

Interventional

Funder types

Other

Identifiers

NCT00726258

2007-00336-20

2007-04

Details and patient eligibility

About

Thoracotomy for lung resection is deemed painful. Ketamine is now a renewed interest in preventing acute postoperative pain. A previous study performed in the service testing the association ketamine/morphine versus morphine PCA, postoperative, for patients who do not benefit from postoperative epidural thoracic surgery, has demonstrated a reduction of postoperative pain associated with a reduction of nocturnal arterial desaturation following surgery when ketamine was added to morphine.

Full description

In this prospective double blind randomized study, intravenous administration of an analgesic dose of ketamine was started since the induction of general anesthesia and continued during the first 48 postoperative hours in association with epidural analgesia.

Enrollment

21 patients

Sex

All

Ages

18 to 85 years old

Volunteers

No Healthy Volunteers

Inclusion criteria

Subject between 18 and 85 years
subject of both sexes
subject operated in the service of thoracic surgery of a lobectomy by thoracotomie lateral or postlaterale subject
subject operated in settled surgery

Exclusion criteria

Against indication in the epidural insanity,
confusionnel, patient psychotic
treatment in the long price by medicine which can interfere on the pain (morphine, antidepressants, psychotropic treatment)