Association of Leucocyte Telomere Length With DPAS Score in Skin Aging

Dr.dr.Irma Bernadette, SpKK (K)

Status: Enrolling

Conditions: Aging; Skin Laxity

Treatments: Genetic: Leucocyte Telomere Length from blood draw

Study type: Interventional

Funder types: Other

Identifiers

NCT06501547

tes

Details and patient eligibility

About

The goal is to know the profile of photoaging based on clinical examination, Dermoscopic Photoaging Scale and leucocyte telomere length

The main questions of Research are:

• what is the profile of photoaging based on clinical examination results in skin aging
• what is the profile of photoaging based on DPAS Score in skin aging
• what is the profile of leucocyte telomere length in skin aging

Participants are female and male with the age of 29-31 years old and 59-61 years old. They will be examined by dermatovenereologist and will be photographed in 5 positions, they will get dermocopy on forehead, right cheek , left cheek, and chin, and their blood will be drawn about 10 mL in order to get the profile of leucocyte telomere length

Full description

Skin aging is a process of deterioration in the physiological structure and function of the skin that significantly increases in the 4th and 5th decades of life. Skin aging is a combination of physiological and pathological aging. Physiological change cannot be avoided and mandatory for everyone, pathological aging ir extrinsic aging is an abnormal skin condition caused by cigarettes, pollution and ultraviolet (UV). In general, the clinical characteristics of skin aging consist of pigmentation changes, hydration disorders, the appearance of wrinkles and skin tumors. The photoaging assessment was first proposed in 1996 by Dr. Richard Glogau, The Glogau scale assesses photoaging based on clinical assessment grouped into 4 categories, namely types I, II, III, and IV,where each type is graded by the severity of wrinkles, namely from mild, moderate, advanced, and severe. Isik et al. developed an instrument for quantitative skin aging assessment using dermoscopy. This examination is non-invasive and is expected to provide a more objective assessment. There are four facial regions assessed in the DPAS score calculation: forehead, right cheek, left cheek, and chin. The sum of the scores of the four regions is assessed based on 11 parameters, with a maximum final score of 44. Telomeres are repetitive DNA-Protein complexes located at the ends of chromosomes of eukarotic cells, and their function is to maintain chromosome stability during cell division, by protecting chromosomes from degradation and fusion. Many factors affect telomere length, such as body mass index, hormonal therapy, antioxidant intake, chronic diseases, and gender. Research by son et al. found that telomere length shortening was validated to increase the odds of skin aging (OR=0.96, 95% CI: 0.9332-0.99566, P= 0.03) Telomeres are closely linked to cellular aging, especially in dermal cells and telomere shortening in skin fibroblasts may lead to epidermal aging and barrier function defectcs.

Enrollment: 20 estimated patients

Sex: All

Ages: 29 to 61 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Female and Male (age 29-31 years old and 59-61 years old
• signs of aging

Exclusion criteria

• pregnant or breastfeeding
• have disease or genetic problem

Trial design

Primary purpose: Diagnostic

Allocation: Randomized

Interventional model: Parallel Assignment

Masking: Single Blind

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20 participants in 2 patient groups

lifestyle counseling

Experimental group

Description:

patient will be asked about the mean of sun exposure per week

Treatment:

Genetic: Leucocyte Telomere Length from blood draw

Clinical examination

Experimental group

Description:

patients's face were assessed by the doctor by using Glogau scale and the doctor will perform dermoscopic tes to assess dermoscopic photoaging scale (DPAS) score to obtain the score of skin aging

Treatment:

Genetic: Leucocyte Telomere Length from blood draw