Association of Macular Pigment Optical Density (MPOD) and Genetic Variants in Complement Factor H in Subjects With Choroidal Neovascular (CNV)

Sequenom

Status: Completed

Conditions: Choroidal Neovascular Age-related Macular Degeneration; Age-related Macular Degeneration

Study type: Observational

Funder types: Industry

Identifiers

NCT01682382

SQNM-AMD-103

Details and patient eligibility

About

Subjects with wet AMD, dry AMD, and age-matched controls will undergo routine occular measurements, will provide a blood and cheek cell sample, and will have macular pigment optical density (MPOD) measured to determine if there is an association between genetics, MPOD and the risk of progression to wet AMD.

Enrollment: 45 patients

Sex: All

Ages: 60+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• subject is diagnosed with either CNV, dry AMD or is an age-matched control
• self reported as non-Hispanic Caucasian
• 60 years of age or older
• provides signed and dated informed consent
• agrees to provide 10 mL of whole blood and two buccal swabs

Exclusion criteria

• previous donation under this protocol

Trial design

45 participants in 3 patient groups

choroidal neovascular (CNV) AMD subjects

Description:

Subjects diagnosed with CNV (AREDS Grade 4b)

dry AMD subjects

Description:

Subjects diagnosed with dry AMD (AREDS Grade 3)

age-matched controls

Description:

Subjects without AMD (AREDS Grade 1)