Association of Mean Platelet Volume and Cardiovascular Disease in Children With End Stage Renal Disease.

Isfahan University of Medical Sciences

Status

Completed

Conditions

Hemodialysis Complication

Peritoneal Dialysis Complication

Children

End Stage Renal Disease

Cardiovascular Diseases

Left Ventricular Hypertrophy

Carotid Intimal Media Thickness

Mean Platelet Volume

Treatments

Other: Blood sampling

Diagnostic Test: Imaging

Study type

Observational

Funder types

Other

Identifiers

NCT03759002

395723

Details and patient eligibility

About

Cardiovascular disease (CVD) is the major risk factor for death in end stage renal diseases (ESRD). Approximately 80% of ESRD patients have some degrees of left ventricular abnormalities at initiation of dialysis. Carotid intima media thickness (CIMT) has been widely accepted as an useful marker to assess CVD in ESRD children. In addition, cardiac mechanics parameters are used to evaluate cardiac function more precisely. However, measuring CIMT and cardiac mechanics parameters are expensive and difficult to perform as a routine method. Mean platelet volume (MPV) is a hematological index which shows the size of platelets. Uremic state causes inflammatory condition that affects MPV. Previous studies on people with normal renal function have shown that this parameter can also have association with CVD. However the data in children with ESRD is scarce. The aim of this study is to find a simple hematologic marker to use regularly in ESRD children finding patients at risk of CVD. Therefore, we will investigate the relationship between mean platelet volume and CIMT and cardiac mechanic parameters in children with ESRD.

Enrollment

102 patients

Sex

All

Ages

Under 18 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

Children under 18 years who have being dialyzed (hemodialysis or peritoneal dialysis) regularly more than 6 months, as case group.
Age and gender matched healthy children who have been referred for routine medical examination.

Exclusion criteria

Patients with uncontrolled hypertension (until being stabled)
Patients on any kind of antithrombotic agents or NSAIDs
Severe obesity
Diabetes patients
Patients with a past history of CVD or stroke in the last 6 months
Passive smokers who contacted daily with high smokers in their houses
Patients with known hematologic diseases or malignancies (such as Fanconi Anemia)
Uncontrolled hypothyroid or hyperthyroid patients
Patients with recent (in the last 4 weeks) catheter or exit -site infection.