Association of Midlife Dietary and Lifestyle Factors on Cardiac Functional Changes in the Elderly (CardiacAging)

Singapore Health Services (SingHealth)

Status: Unknown

Conditions: Ageing

Treatments: Other: Body Fat Mass Analysis; Other: Genetic Testing (Blood); Other: Tonometry; Other: Cardiovascular Magnetic Resonance Imaging (MRI); Other: Hand-Grip Strength Measurement; Other: Echocardiography

Study type: Observational

Funder types: Other

Identifiers

NCT02791139

2014/628/C

Details and patient eligibility

About

The investigators aim to investigate the association of midlife dietary and lifestyle factors on cardiac functional changes in the elderly. The investigators hypothesize that even in those without clinically manifest cardiovascular disease, the extent of underlying abnormalities in cardiovascular structure and function in the elderly would be independently related to midlife dietary and lifestyle factors.

Full description

This proposal will investigate how midlife factors in diet and lifestyle affect various aspects of cardiac structure and function related to ageing. The investigators plan to conduct the study among a sub-cohort of 600 participants from the Singapore Chinese Health Study. Comprehensive information on diet and lifestyle factors had been collected at recruitment and updated in two subsequent follow-up interviews. Candidate nutrition-related blood biomarkers such as vitamins D, homocysteine, fatty acids (short, medium and long-chain) and lipids (LDL, HDL, triglycerides) will be analyzed from samples obtained between 1999 and 2004. The investigators will study effects of smoking, alcohol consumption, sleep duration, physical activity and diet on cardiac ageing. The investigators will study overall dietary pattern, intake of specific items such as fatty acids, soy food, coffee and tea beverages, from validated food frequency questionnaires (FFQ), and nutrients from questionnaire information from this cohort previously obtained.

These nutrient and lifestyle factors will be studied individually, and for their joint or interactive effects on cardiac ageing measurements. Quantitative cardiac ageing-related outcome parameters describing cardiac mass, systolic and diastolic function, and vessel distensibility will be examined by cardiac magnetic resonance imaging. Maximum oxygen uptake (VO2 max) will be calculated based on age, gender, waist circumference, resting heart rate, and exercise habits. Body composition will be analysed by a body composition analyser machine onto which subjects stand on.

Enrollment: 800 estimated patients

Sex: All

Ages: 60+ years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Who were younger than 60 years at recruitment
• Had been interviewed at baseline and at the two follow-up interviews
• Had provided biospecimens for research previously before the age of 65 years (2000-2004)
• Who will be 65 years or older by 2013

Exclusion criteria

• Any known history of heart disease or stroke
• Anticipated life expectancy < 1 year
• Unable to provide written informed consent to participate in the study
• Patients with cancer
• Patients with chronic renal disease
• Any metallic implants

Trial design

800 participants in 2 patient groups

Control

Description:

Healthy Volunteers will undergo the following studying procedures: Cardiovascular Magnetic Resonance Imaging (CMRI) Echocardiography Tonometry Genetic Testing (Blood) Hand-Grip Strength Measurement Body Fat Mass Analysis

Treatment:

Other: Genetic Testing (Blood)

Other: Hand-Grip Strength Measurement

Other: Cardiovascular Magnetic Resonance Imaging (MRI)

Other: Echocardiography

Other: Body Fat Mass Analysis

Other: Tonometry

Ageing

Description:

Ageing cohort will undergo the following studying procedures: Cardiovascular Magnetic Resonance Imaging (CMRI) Echocardiography Tonometry Genetic Testing (Blood) Body Fat Mass Analysis

Treatment:

Other: Genetic Testing (Blood)

Other: Cardiovascular Magnetic Resonance Imaging (MRI)

Other: Echocardiography

Other: Body Fat Mass Analysis

Other: Tonometry