Association of Mood With Risk for Atherosclerosis (AuRA)

Johns Hopkins University

Status: Completed

Conditions: Hypertension; Elevated Blood Pressure; Vascular Stiffness; Overweight and Obesity; Mood Disorders; Sleep

Treatments: Diagnostic Test: Cardiovascular Assessments; Diagnostic Test: Laboratory assessments; Behavioral: Emotional/ Behavioural assessments; Diagnostic Test: Actigraphy

Study type: Observational

Funder types: Other; NIH

Identifiers

NCT04298944

IRB00226838

P50MH115842-01 (U.S. NIH Grant/Contract)

Details and patient eligibility

About

The investigators will aim to determine the association of mood disorders (MDO) with preclinical and clinical cardiovascular (CVD) risk factors among children.

The investigators will also aim to identify traditional and non traditional predictors of CVD risk among children with MDO.

Full description

This research is being done to determine if mood disorders in children have an impact on stiffness of arteries and/or cause the arteries to not work as well and if MDOs impact blood pressure over a 24 hour period of time.The investigators also want to determine if children with mood disorders have any risk factors or blood tests that can predict how stiff arteries are or how well arteries function and if these are associated with cardiovascular disease risk. The investigators also want to determine if children with mood disorders have greater adverse childhood experiences, worse emotional regulation and poorer quality of sleep. The investigators hope that information from this study could help in earlier detection of cardiovascular disease risk in children.

Enrollment: 37 patients

Sex: All

Ages: Under 22 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Children Ages ≤ 22 years old
• Enrolled in the CHAMPION Trial and have agreed to be contacted for future studies or children who visit PMP clinic and have MDO and a healthy weight or participants in the Be-HealthY Cohort whose data indicate no history of MDO.

Exclusion criteria

• Not able to speak English
• Unable to lie supine
• Significant Arrhythmia
• If participant has used vaso-active drugs the morning of the test (tobacco, caffeine decongestants, or asthma medications).

Trial design

37 participants in 3 patient groups

BeHealthY Cohort

Description:

Children from BeHealthY cohort who are obese/overweight but do not have mood disorders are eligible for this study. The children will be given additional questionnaires to assess emotional/behavioral well being.

Treatment:

Diagnostic Test: Cardiovascular Assessments

Behavioral: Emotional/ Behavioural assessments

Diagnostic Test: Actigraphy

Diagnostic Test: Laboratory assessments

CHAMPION trial Cohort

Description:

Children who are overweight/obese and have severe mental illness, and who have agreed to be contacted for future research. Tests will be done on all participants which includes cardiovascular assessments, actigraphy, laboratory assessments and emotional/behavioral assessments.

Treatment:

Diagnostic Test: Cardiovascular Assessments

Behavioral: Emotional/ Behavioural assessments

Diagnostic Test: Actigraphy

Diagnostic Test: Laboratory assessments

Pediatric Medical Psychiatric (PMP) Clinic Cohort

Description:

Children from the PMP Clinic who have severe mental illness but healthy weight. Tests will be done on all participants which includes cardiovascular assessments, actigraphy, laboratory assessments and emotional/behavioral assessments.

Treatment:

Diagnostic Test: Cardiovascular Assessments

Behavioral: Emotional/ Behavioural assessments

Diagnostic Test: Actigraphy

Diagnostic Test: Laboratory assessments