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The purpose of this study is to explore the relationship between periodontal disease and coronary artery disease through changes in the gut microbiome. In addition, the investigators aim to find possible periodontal pathogens that have association with cardiovascular disease.
Full description
The previous studies have reported the associations among cardiovascular disease, periodontitis, and gut microbiome dysbiosis. However, there is a lack of evidences about the axis of association from oral-gut-cardiovascular disease. The investigators hypothesized that periodontal disease might induce dysbiosis of gut microbiome and dysbiosis might have a role in cardiovascular disease (as called "oro-gut-vascular axis"). The investigators aim to prove this hypothesis through this case-control, cross-sectional study.
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Inclusion criteria
-Patients aged from 19 to 80 years who underwent invasive coronary angiography for clinical necessity, with informed consent
Exclusion criteria
450 participants in 2 patient groups
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Central trial contact
Jong-Won Ha
Data sourced from clinicaltrials.gov
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