Association of Plasma N-terminal Pro-Brain Natriuretic Peptide Levels With the Burden of Coronary Artery Disease (BNP-CAD)

IRCCS Ospedale San Raffaele

Status: Enrolling

Conditions: Stable Chronic Angina; Chronic Coronary Total Occlusion; Coronary Arterial Disease (CAD); Chronic Coronary Syndrome; NT-pro-BNP

Treatments: Diagnostic Test: BNP

Study type: Observational

Funder types: Other

Identifiers

NCT07013344

BNP-CAD-HSR-2025

Details and patient eligibility

About

This study aim to investigate the association between plasma NT-proBNP levels and the presence, extent and severity of stenosis in patients with suspected coronary artery disease.

Full description

The investigators prospectively measured plasma NT-proBNP levels in consecutive patients referred to the center for elective diagnostic coronary angiography due to symptoms or signs of coronary artery disease over a two- year period. Patients with conditions known to elevate NT-proBNP levels, including heart failure, severe valvular disease, atrial fibrillation, severe chronic kidney disease (eGFR < 30 mL/min), prior coronary artery bypass grafting, or age over 80 years, were excluded.

Enrollment: 800 estimated patients

Sex: All

Ages: 18+ years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• patient referred for elective coronary angiography due to suspected CAD.
• NT-proBNP measurement during hospitalization

Exclusion criteria

• heart failure
• severe valvular disease
• atrial fibrillation
• severe chronic kidney disease (eGFR < 30 mL/min)
• prior coronary artery bypass grafting
• age over 80 years