Association of Polymorphisms in the Androgen Receptor Gene and Finasteride Response in Women With Androgenetic Alopecia

HairDx

Status and phase: Completed; Phase 1

Conditions: Androgenetic Alopecia

Treatments: Drug: Finasteride

Study type: Interventional

Funder types: Industry

Identifiers

NCT01052870

HairDx2009

Details and patient eligibility

About

Previous studies of finasteride treatment in women with hair loss have failed to show positive results, yet, some women have responded anecdotally. Given that polymorphisms of the androgen receptor gene which confer androgen sensitivity impact male response to finasteride therapy, it was hypothesized that the same polymorphism in women may identify the group that will respond. This study is designed to test the impact of finasteride therapy on hair loss in postmenopausal women.

Full description

Androgen sensitivity in the cell is determined by the number of Cytosine-Adenine-Guanine repeats in the Androgen Receptor gene. Lower CAG repeats have been associated in previous studies with androgenic conditions such as acne, hirsutism and hair loss in men and women. Keeping this in mind, we tested women with hair loss in the frontal or vertex area, for their AR genotype. Patients were randomized to placebo or 1 mg finasteride therapy for 6 months. Global photographs and 2 tatooed areas of 1cm2 each were measured monthly to assess global appearance and hair counts for medication impact.

Enrollment: 12 patients

Sex: Female

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• women with hair loss

Exclusion criteria

• pre menopausal,
• metabolic or medication or non-androgenetic causes of hair loss,
• diffuse hair loss

Trial design

Primary purpose: Treatment

Allocation: Randomized

Interventional model: Single Group Assignment

Masking: Single Blind

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12 participants in 2 patient groups

androgen receptor gene polymorphism

Other group

Description:

Medication response will be assessed according to androgen receptor genotype

Treatment:

Drug: Finasteride

finasteride

Active Comparator group

Description:

medication for treating androgenetic alopecia in women

Treatment:

Drug: Finasteride