Association of TTGA (Tissue Transglutaminase Antibody) and Histopathologic Findings in Thyroidectomy Patients

Diskapi Yildirim Beyazit Training and Research Hospital

Status: Unknown

Conditions: Thyroid Fibrosis

Treatments: Other: Measuring of fibrosis in thyroid specimen and measuring of Anti-tTG in serum samples

Study type: Interventional

Funder types: Other

Identifiers

NCT04974255

59/02

Details and patient eligibility

About

Gluten sensitivity is the most common auto-immune disease associated with auto-immune thyroiditis. This association is through elevated anti-Tissue transglutaminase (Anti-tTG) levels both in Celiac disease and thyroiditis. In our study we tried to find if there is any correlation in between Anti-tTG and degree of fibrosis in thyroid tissue (Post-operative specimen).

Full description

Most common auto-immune disease associated with Celiac disease is autoimmune thyroiditis. This association in between Celiac disease and aout-immune thyroiditis is related with asymptomatic rise in anti-tTG levels. In our study, we planned to show that if there is any correlation of thyroiditis related fibrosis in thyroid tissue with anti-tTG IgA ( immune-globulin A) and IgG (immune-globulin G).

Enrollment: 198 patients

Sex: All

Ages: 18 to 88 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Thyroiditis patients operated for any indication

Exclusion criteria

• Patients with known IgA deficiency

Trial design

Primary purpose: Supportive Care

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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198 participants in 1 patient group

Operated Patients

Experimental group

Description:

Measurement of fibrosis degree and Anti-tTG levels

Treatment:

Other: Measuring of fibrosis in thyroid specimen and measuring of Anti-tTG in serum samples