Association Study Between CYP1A2 Gene Polymorphisms and Metabolism of Theophylline

XiaoGuang Zou

Status: Completed

Conditions: Chronic Obstructive Pulmonary Disease

Treatments: Drug: Theophylline

Study type: Interventional

Funder types: Other

Identifiers

NCT03015090

2016D01C013

Details and patient eligibility

About

The aim of this study is to determine whether common CYP1A2 gene polymorphisms effect metabolism of theophylline in Han and Uygur Patients with chronic obstructive pulmonary disease patients.

Enrollment: 110 patients

Sex: All

Ages: 18 to 75 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• Aged 18-75 years,Weight 40-80kg COPD patients, male or female; regularly visiting our hospital; taking a sustained-release preparation of theophylline continuously for at least 2 weeks

Exclusion criteria

• Patients with renal or hepatic dysfunction; Patients with congestive heart failure; Patients with hypothyroidism or hyperthyroidism; Patients currently taking drugs likely to effect theophylline metabolism or who had taken such drugs in the preceding week; Patients with extreme obesity Patients with very severe Chronic Obstructive Pulmonary Disease(COPD)

Trial design

Primary purpose: Other

Allocation: N/A

Interventional model: Single Group Assignment

Masking: None (Open label)

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110 participants in 1 patient group

theophylline

Experimental group

Treatment:

Drug: Theophylline