Association Study of Gene Polymorphisms With Cardiac Performance

University Hospital Essen

Status: Unknown

Conditions: Coronary Artery Disease; Genetic Polymorphism; Hemodynamics

Study type: Observational

Funder types: Other

Identifiers

NCT00730899

HOT-001

Details and patient eligibility

About

The purpose of this study is to determine whether polymorphisms in G protein subunits, namely Galphas and Galphaq, are associated with altered cardiac performance in heart failure patients.

Full description

G Protein pathways plays a pivotal role in mediating positive inotropy and cardiac hypertrophy by transducing signals of neurohormones in cardiomyocytes. Single nucleotide polymorphisms (SNPs) in the G protein subunits Galphas and Galphaq have been shown to result in altered protein expression. We now want to examine whether G Protein polymorphisms alter NYHA functional class, and hemodynamic variables in patients with coronary artery disease scheduled for coronary artery bypass grafting .

Enrollment: 500 estimated patients

Sex: All

Ages: 18 to 80 years old

Volunteers: No Healthy Volunteers

Inclusion criteria

• clinical diagnosis of coronary artery disease
• patients scheduled for coronary artery bypass grafting

Exclusion criteria

• emergency operation
• combined vitium