Associations Analysis Between Lifestyle and Osteoporosis

Tongji University

Status: Completed

Conditions: Osteoporosis of Disuse With Current Pathological Fracture

Study type: Observational

Funder types: Other

Identifiers

NCT02451397

OPLA_Dr.Tang

Details and patient eligibility

About

A large-scale, community-based, cross-sectional study was conducted to evaluate the extent to which lifestyle was associated with osteoporosis among the Chinese population by using self-reported questionnaire methods.

Full description

A large-scale, community-based, cross-sectional study was conducted to evaluate the extent to which lifestyle was associated with osteoporosis among the Chinese population by using self-reported questionnaire methods. More than 3000 participants were recruited in communities in Shanghai. Data involved in demographic information, lifestyle, dietary habits, medical history and clinical biomarkers were collected. Every participants were measured bone mineral density (BMD g/cm2) at calcaneus by standardized quantitative ultrasound (QUS, Hologic Inc., Bedford, MA, USA) utilizing T-scores based on WHO criteria. A standard statistical analysis including univariate and multiple variables regression analysis to explore the risk or preventive factors involved in Chinese lifestyle associated with osteoporosis.

Enrollment: 3,100 patients

Sex: All

Ages: 30 to 90 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• Participants aged 30-90 years were recruited from rural and urban communities in Shanghai.

Exclusion criteria

• Some participants with chronic diseases and conditions that might potentially affect bone mass, structure, or metabolism were excluded. Briefly, the exclusion criteria were as follows: a history of

  1. serious residual effects of cerebral vascular disease;
  2. serious chronic renal disease (Glomerular filtration rate - GFR < 30 mL/min/1.73m2);
  3. serious chronic liver disease or alcoholism;
  4. significant chronic lung disease;
  5. corticosteroid therapy at pharmacologic levels;
  6. evidence of other metabolic or inherited bone disease, such as hyper- or hypoparathyroidism, Paget disease, osteomalacia, or osteogenesis imperfecta;
  7. recent (within the past year) major gastrointestinal disease, such as peptic ulcer, malabsorption, chronic ulcerative colitis, regional enteritis, or significant chronic diarrhea;
  8. Cushing syndrome;
  9. hyperthyroidism; and
  10. any neurologic or musculoskeletal condition that would be a non-genetic cause of low bone mass.

Trial design

3,100 participants in 1 patient group

Dr.Tang's research group

Description:

Chinese lifestyle associated with osteoporosis