Associations of Exposure to Bisphenol A With Blood Pressure and Epigenetic Change
Status
Completed
Conditions
Hypertension
Treatments
Other: Can 1
Other: Can 2
Other: Glass
Details and patient eligibility
About
- Bisphenol A(BPA) is an endocrine disrupting chemical, which mimics the action of estrogen.
- Previous studies reported that BPA exposure is associated with increased risk of cardiovascular diseases.
- Exposure to BPA occur mainly through oral route, and epoxy coating of canned food is one of the well established source.
- The investigators hypothesis is that increased BPA exposure from canned beverage would disrupt normal physiology in a short term.
- In the present trial the investigators are to investigate whether increased BPA exposure by consuming canned beverage actually affect cardiovascular indices and epigenetic feature.
- For this aim, the investigators will conduct a cross-over trial.
Enrollment
60 patients
Sex
All
Ages
60 to 85 years old
Volunteers
Accepts Healthy Volunteers
Inclusion criteria
- Reside in Seoul
- Who provided Informed consent
Exclusion criteria
- Who has cancer
- Who has disease or disorder of liver, nervous system, endocrine system, cardiovascular system
- Who does not provieded informed consent
Trial design
Primary purpose
Basic Science
Allocation
Randomized
Interventional model
Crossover Assignment
Masking
Single Blind
60 participants in 3 patient groups
Glass
Active Comparator group
Description:
consume beverage in glass first and cross over to other interventions
Treatment:
Other: Glass
Other: Can 2
Other: Can 1
Can 1
Experimental group
Description:
consume one canned beverage and a glass bottled beverage first and cross over to other interventions
Treatment:
Other: Glass
Other: Can 2
Other: Can 1
Can 2
Experimental group
Description:
Consume two canned beverage first and cross over to other interventions
Treatment:
Other: Glass
Other: Can 2
Other: Can 1
Trial contacts and locations
1
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Data sourced from clinicaltrials.gov
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