Associations of Vitamin D Receptor ApaI and Tru9I Polymorphisms With the Risk of Primary Open-angle Glaucoma

Lv Yingjuan

Status: Completed

Conditions: Primary Open- Angle Glaucoma

Treatments: Other: Vitamin D receptor polymorphic analysis

Study type: Observational

Funder types: Other

Identifiers

NCT02805231

tjykdxykyy4

Details and patient eligibility

About

This study investigated whether vitamin D receptor gene polymorphism is altered in primary open-angle glaucoma subjects carrying the risk allele.Primary open-angle glaucoma patients and age-matched people in the Han population were enrolled. Vitamin D receptor polymorphic analysis was studied by polymerase chain reaction-restriction fragment length polymorphism technique.

Enrollment: 300 patients

Sex: All

Ages: 55 to 65 years old

Volunteers: Accepts Healthy Volunteers

Inclusion criteria

• intraocular pressure greater than 22 mmHg with two or more medications wide anterior chamber angle glaucomatous optic neuropathy (Glaucomatous optic nerve damage was defined as cup-to-disc ratio higher than 0.7 or focal loss of the nerve fiber layer (notch) associated with a consistent glaucomatous visual field defect) visual field loss consistent with optic nerve damage and visual fields were performed by using standard automated perimetry

Exclusion criteria

• the presence of any secondary glaucoma including exfoliation syndrome or a history of ocular trauma high myopia macular degeneration other ocular diseases a known history of systemic diseases and administration of vitamin D3 or other analog

Trial design

300 participants in 2 patient groups

primary open-angle glaucoma patients

Description:

vitamin D receptor polymorphic analysis was studied by real-time polymerase-chain reaction high resolution melting analysis in primary open-angle glaucoma patients.

Treatment:

Other: Vitamin D receptor polymorphic analysis

randomly age-matched people

Description:

vitamin D receptor polymorphic analysis was studied by real-time polymerase-chain reaction high resolution melting analysis in randomly age-matched people.

Treatment:

Other: Vitamin D receptor polymorphic analysis