ClinicalTrials.Veeva

Menu

Associations of Vitamin D Receptor ApaI and Tru9I Polymorphisms With the Risk of Primary Open-angle Glaucoma

L

Lv Yingjuan

Status

Completed

Conditions

Primary Open- Angle Glaucoma

Treatments

Other: Vitamin D receptor polymorphic analysis

Study type

Observational

Funder types

Other

Identifiers

NCT02805231
tjykdxykyy4

Details and patient eligibility

About

This study investigated whether vitamin D receptor gene polymorphism is altered in primary open-angle glaucoma subjects carrying the risk allele.Primary open-angle glaucoma patients and age-matched people in the Han population were enrolled. Vitamin D receptor polymorphic analysis was studied by polymerase chain reaction-restriction fragment length polymorphism technique.

Enrollment

300 patients

Sex

All

Ages

55 to 65 years old

Volunteers

Accepts Healthy Volunteers

Inclusion criteria

  • intraocular pressure greater than 22 mmHg with two or more medications wide anterior chamber angle glaucomatous optic neuropathy (Glaucomatous optic nerve damage was defined as cup-to-disc ratio higher than 0.7 or focal loss of the nerve fiber layer (notch) associated with a consistent glaucomatous visual field defect) visual field loss consistent with optic nerve damage and visual fields were performed by using standard automated perimetry

Exclusion criteria

  • the presence of any secondary glaucoma including exfoliation syndrome or a history of ocular trauma high myopia macular degeneration other ocular diseases a known history of systemic diseases and administration of vitamin D3 or other analog

Trial design

300 participants in 2 patient groups

primary open-angle glaucoma patients
Description:
vitamin D receptor polymorphic analysis was studied by real-time polymerase-chain reaction high resolution melting analysis in primary open-angle glaucoma patients.
Treatment:
Other: Vitamin D receptor polymorphic analysis
randomly age-matched people
Description:
vitamin D receptor polymorphic analysis was studied by real-time polymerase-chain reaction high resolution melting analysis in randomly age-matched people.
Treatment:
Other: Vitamin D receptor polymorphic analysis

Trial contacts and locations

1

Loading...

Data sourced from clinicaltrials.gov

Clinical trials

Find clinical trialsTrials by location
© Copyright 2025 Veeva Systems